Tri-Beta Advisor Advisor
Department of Biology
Loyola University Maryland
4501 North Charles Street
Baltimore, MD 21210-2699
Office: DS 242
Office tel: 410-617-5244
Areas of Interest
Reproductive Physiology and Forensic Entomology
A.B - Ripon College, Ripon Wisconsin (Major: Biology, Minor: Chemistry)
Ph.D. - University of Wisconsin-Milwaukee
Postdoctoral Fellowship – Oregon Regional Primate Research Center
Research done in my laboratory is very collaborative in nature. I am involved in a number of research projects, dividing along two main lines of interest. I am interested in the intersection of metabolism and reproduction. While doing my postdoctoral fellowship at the Oregon Primate Center, I was involved studies trying to determine how energy load translated into neuronal activation of the brain areas that control reproduction. I was very interested in how certain hormones, mainly leptin, regulated distinct parts of the brain that were involved in ingestive (or eating) behavior and reproductive ability. Since coming to Loyola, I have maintained that interest and expanding to trying to understand how hormones from the adipose tissue (now termed adipokines) regulate specific processes in the ovary. For these projects, my collaborators and I use non-human primates as our model. Specifically, we are looking at how the adipokines potentially regulate glucose and in turn how changes in glucose and lipid metabolism then regulate the process of ovulation and potentially the development of the oocyte.
The second line of interest comes mainly from reading forensic detective novels. I have always loved the books written by Patricia Cornwell (and others). Stories referring to detectives using forensic and medical evidence to solve puzzles and sometimes crimes are quite fun to read and interesting to me. So, when presented with the opportunity to do some actual research on methods that forensic scientists might someday use, I was hooked. To date I have collaborated with Dr. David Rivers to understand how fly development (flesh flies and blow flies) is regulated when the flies are reared in varying temperatures due to mass density.
Puttabyatappa, M., Brogan, R.S., VandeVoort, C.A., and C.L. Chaffin. 2010. EGF-like ligands mediate progesterone’s anti-apoptotic action on macaque granulosa cells. Endocrinology Submitted
Brogan, R.S., MacGibeny, M., Mix, S. Thompson, C.T., Puttabyatappa, M., VandeVoort, C.A., and C.L. Chaffin. 2010. Dynamics of intrafollicular glucose, lactate and pyruvate during luteinization of macaque ovarian follicles. Mol.Cell. Endo. submitted (accepted pending revisions).
Kolmakova, A., Wang, J., Brogan, R.S., Chaffin, C.L. and A. Rodriguez. 2010. Deficiency of scavenger receptor class B type I receptor negatively affects progesterone secretion in human granulosa cells. Endocrinology in press
Rivers, D. B., Ciarlo, T., Spelman, M. and R.S. Brogan. 2010. Changes in development and heat shock protein expression in two species of flies [Sarcophaga bullata (Diptera: Sarcophagidae) and Protophormia terraenovae (Diptera: Calliphoridae)] reared in different sized maggot masses. J. Med. Entomol. Jul;47(4):677-89.
Brogan, R.S., Mix, S., Puttabayatappa, M. VandeVorrt, C.A. and C.L. Chaffin. 2009. Expression of the insulin-like growth factor and insulin systems in the luteinizing macaque ovarian follicle. Human Fertility and Sterility. Published online February 24, 2009.
Chaffin, C.L.; Brogan, R.S.; Stouffer, R.L. and C.A. VandeVoort. 2003. Dynamics of myc/max/mad expression of primate granulose cells in vitro. Association with periovulatory proliferation. Endocrinology 144:1249-1256.
If you are interested in these types of research, you might also find the following people interesting as well:
M. Susan Smith, Oregon Regional Primate Research Center and Oregon Health Sciences University
Bill Bass and Jon Jefferson, The Body Farm